PYLa/PGLa

Entry PYLa/PGLa
Uniprot code Q99134
Fasta Q99134
Peptide names PYLa PYLa/PGLa PGLA PGLa
Suborder Mesobatrachia
Family Pipidae
Genus Xenopus
Species Xenopus laevis
Ecozone Afrotropic
Distribution Extreme southern Angola south to Cape Region of Rep. South Africa thence east and north in savanna habitats to north-east-central Central African Republic and southern Sudan and then west to Nigeria; introduced in southern California, Arizona, USA, Mexico, Chile, France, Mexico, Italy, and Java, Indonesia, as well as Ascension Island
Antimicrobial & other activities antibacterial; PGLa: antibacterial, antifungal, antiprotozoa
Tissue Skin, Stomach
Sequence MYKQIFLCLIIAALCATIMAEASAFADADEDDDKRYVRGMASKAGAIAGKIAKVALKALG
RRDS
Length 64
Signal peptide class Class-4
References:
1. for MIC/HC50 PhD disertation (page 48) of Carsten Sachse (2003), Friedrich-Schiller-University Jena. F-Festkoerper-NMR-Untersuchungen zur Orientierung und Dynamik des antimikrobiellen Peptids PGLa in Lipidmembranen;  N. Uematsu and K. Matsuzaki / Biophysical Journal 79 (2000) 2075-2083. Polar Angle as a Determinant of Amphipathic ?-Helix-Lipid Interactions: A Model Peptide Study


Segment type Name Length Amidated Sequence HC50 (μM) MIC E. coli (μM) MIC S. aureus (μM)
Signal   20   MYKQIFLCLIIAALCATIMA    
Prepro15 EASAFADADEDDDKR   
BioactivePYLa24NoYVRGMASKAGAIAGKIAKVALKAL   
BioactivePGLa21YesGMASKAGAIAGKIAKVALKAL90012.73.17