Kininogen-1b

Entry Kininogen-1b
Uniprot code Q90WZ1
Fasta Q90WZ1
Peptide names Maximakinin Kininogen-1b Bradykinin
Suborder Archeobatrachia
Family Bombinatoridae
Genus Bombina
Species Bombina maxima
Ecozone Palearctic, Indomalaya
Distribution Yunnan, southwestern Sichuan, Hubei, Guizhou, and northern Guangxi, China; adjacent northern Vietnam
Antimicrobial & other activities contraction of small intestine smooth muscle cells, relaxation of arterial smooth muscle cells
Tissue Skin
Sequence MRLWFCLSFFIVLCLEHFPETLADERNVPESEEKTEQYLRDLPKINRKGPRPPGFSPFRG
KFHSQSLRDLPKINRKGPRPPGFSPFRGKFHSQSLRDLPKINRKGPRPPGFSPFRGKFHS
QSLRDLPKINRKGPRPPGFSPFRGKFHSQSLRDLPKINRKGPRPPGFSPFRGKFHSQSLR
DLPKINRKGPRPPGFSPFRGKFHSQSHV
Length 208
Signal peptide class Class-5
References:
2. for other activities T. Chen et al. / Peptides 23 (2002) 1547-1555. Bradykinins and their precursor cDNAs from the skin of the fire-bellied toad (Bombina orientalis)


Segment type Name Length Amidated Sequence HC50 (μM) MIC E. coli (μM) MIC S. aureus (μM)
Signal   23   MRLWFCLSFFIVLCLEHFPETLA    
Prepro17 DERNVPESEEKTEQYLR   
BioactiveMaximakinin19NoDLPKINRKGPRPPGFSPFR   
BioactiveBradykinin9NoRPPGFSPFR   
BioactiveMaximakinin19NoDLPKINRKGPRPPGFSPFR   
BioactiveBradykinin9NoRPPGFSPFR   
BioactiveMaximakinin19NoDLPKINRKGPRPPGFSPFR   
BioactiveBradykinin9NoRPPGFSPFR   
BioactiveMaximakinin19NoDLPKINRKGPRPPGFSPFR   
BioactiveBradykinin9NoRPPGFSPFR   
BioactiveMaximakinin19NoDLPKINRKGPRPPGFSPFR   
BioactiveBradykinin9NoRPPGFSPFR   
BioactiveMaximakinin19NoDLPKINRKGPRPPGFSPFR   
BioactiveBradykinin9NoRPPGFSPFR