Caerin 1.11

Entry Caerin 1.11
Uniprot code Q800R9
Fasta Q800R9
Peptide names Caerin 1.11
Suborder Neobatrachia
Family Hylidae
Genus Litoria
Species Litoria caerulea
Ecozone Australasia
Distribution Northern and eastern Australia (except for the Victoria and Tasmania); islands in the Torres Straits; New Guinea (northern lowlands, southern lowlands, and Vogelkop Peninsula); introduced into New Zealand
Antimicrobial & other activities antibacterial
Tissue Skin
Sequence MASLKKSLFLVLFLGFVSVSICEEEKRQEDEDEHEEEGENQEEGSEEKRGLFSVLGSVAK
HVVPRVVPVIAEHLG
Length 75
Signal peptide class Class-1
References:
2. for other activities D. Vanhoye et a. / European Journal of Biochemistry 270 (2003) 2068-2081. Antimicrobial peptides from hylid and ranin frogs originated from a 150-million-year-old ancestral precursor with a conserved signal peptide but a hypermutable antimicrobial domain


Segment type Name Length Amidated Sequence HC50 (μM) MIC E. coli (μM) MIC S. aureus (μM)
Signal   22   MASLKKSLFLVLFLGFVSVSIC    
Prepro27 EEEKRQEDEDEHEEEGENQEEGSEEKR   
BioactiveCaerin 1.1125YesGLFSVLGSVAKHVVPRVVPVIAEHL