Caerin-1.1

Entry Caerin-1.1
Uniprot code Q800R2
Fasta Q800R2
Peptide names Caerin-1.1 Caerin 1.1
Suborder Neobatrachia
Family Hylidae
Genus Litoria
Species Litoria caerulea
Ecozone Australasia
Distribution Northern and eastern Australia (except for the Victoria and Tasmania); islands in the Torres Straits; New Guinea (northern lowlands, southern lowlands, and Vogelkop Peninsula); introduced into New Zealand
Antimicrobial & other activities antibacterial, anticancer, antifungal, nNOS inhibitor
Tissue Skin
Sequence MASLKKSLFLVLLLGFVSVSICEEEKRQEDEDEHEEEGESQEEGSEEKRGLLSVLGSVAK
HVLPHVVPVIAEHLG
Length 75
Signal peptide class Class-1
References:
1. for MIC/HC50 M.A. Apponyi et al. / Peptides 25 (2004) 1035-1054. Host-defence peptides of Australian anurans: structure, mechanism of action and evolutionary significance;  P.A. Wabnitz et al. / European Journal of Biochemistry 267 (2000) 269-275. Differences in the skin peptides of the male and female Australian tree frog Litoria splendida. The discovery of the aquatic male sex pheromone splendipherin, together with phe8 caerulein and a new antibiotic peptide caerin 1.10
2. for other activities R.J. Jackway et al. / Peptides 32 (2011) 161-172. Skin peptide and cDNA profiling of Australian anurans: genus and species identification and evolutionary trends


Segment type Name Length Amidated Sequence HC50 (μM) MIC E. coli (μM) MIC S. aureus (μM)
Signal   22   MASLKKSLFLVLLLGFVSVSIC    
Prepro27 EEEKRQEDEDEHEEEGESQEEGSEEKR   
BioactiveCaerin-1.125YesGLLSVLGSVAKHVLPHVVPVIAEHL  1.16