Kininogen-1

Entry Kininogen-1
Uniprot code Q7T2V5
Fasta Q7T2V5
Peptide names bradykinin Kininogen-1
Suborder Neobatrachia
Family Ranidae
Genus Odorrana
Species Odorrana schmackeri
Ecozone Palearctic, Indomalaya
Distribution Southern and south-central China in Henan, Shaanxi, Gansu, Sichuan, Guizhou, Hubei, Anhui, Jiangsu, Zhejiang, Hunan, Guangdong and Guangxi Provinces, at 200-1400 m elevation; reports from Vietnam and Thailand require confirmation
Antimicrobial & other activities contraction of small intestine smooth muscle cells, relaxation of arterial smooth muscle cells
Tissue Skin
Sequence MFTLKKSLLLLFFLGTINLSLCKQERDADEDENEREAKVEDVKRAGYSRMIRRPPGFSPF
RVAPASSLKRDADEDENEREAKVEDVKRAGYARMIRRPPGFSPFRVAPASSLKRDADEDE
NEREAKVEDVKRAGYSRMIRRPPGFSPFRVAPASSLKRGADEDENEREAKVEDVKRAGYS
RMIRRPPGFSPFRVAPASSLKRDADEDENEREAKVEDVKRAGYARMIRRPPGFSPFRVAP
ASSLKRDADEDENEREAKVEDVKRAGYSRMIRRPPGFSPFRVAPASSLKRGADEDENERE
AKVEDVKRAGYSRMIRRPPGFSPFRIAPAIV
Length 331
Signal peptide class Class-1
References:
2. for other activities T. Chen et al. / Peptides 23 (2002) 1547-1555. Bradykinins and their precursor cDNAs from the skin of the fire-bellied toad (Bombina orientalis)


Segment type Name Length Amidated Sequence HC50 (μM) MIC E. coli (μM) MIC S. aureus (μM)
Signal   22   MFTLKKSLLLLFFLGTINLSLC    
Prepro30 KQERDADEDENEREAKVEDVKRAGYSRMIR   
Bioactivebradykinin9NoRPPGFSPFR   
Prepro35 VAPASSLKRDADEDENEREAKVEDVKRAGYARMIR   
Bioactivebradykinin9NoRPPGFSPFR   
Prepro35 VAPASSLKRDADEDENEREAKVEDVKRAGYSRMIR   
Bioactivebradykinin9NoRPPGFSPFR   
Prepro35 VAPASSLKRGADEDENEREAKVEDVKRAGYSRMIR   
Bioactivebradykinin9NoRPPGFSPFR   
Prepro35 VAPASSLKRDADEDENEREAKVEDVKRAGYARMIR   
Bioactivebradykinin9NoRPPGFSPFR   
Prepro35 VAPASSLKRDADEDENEREAKVEDVKRAGYSRMIR   
Bioactivebradykinin9NoRPPGFSPFR   
Prepro35 VAPASSLKRGADEDENEREAKVEDVKRAGYSRMIR   
Bioactivebradykinin9NoRPPGFSPFR