Maximin 3/H3 type 2

Entry Maximin 3/H3 type 2
Uniprot code Q58T70
Fasta Q58T70
Peptide names Maximin 3/H3 type 2 Maximin 3 Maximin H3 Maximin 25
Suborder Archeobatrachia
Family Bombinatoridae
Genus Bombina
Species Bombina maxima
Ecozone Palearctic, Indomalaya
Distribution Yunnan, southwestern Sichuan, Hubei, Guizhou, and northern Guangxi, China; adjacent northern Vietnam
Antimicrobial & other activities antibacterial, antifungal, anticancer, anti-HIV-1, spermicidal; Maximin H3: antibacterial, antifungal
Tissue Skin, Brain
Sequence MNFKYIVAVSFLIASAYARSVQNDEQSLSQRDVLEEEESLREIRGIGGKILSGLKTALKG
AAKELASTYLHRKRTAEEHEVMKRLEAVMRDLDSLDYPEEAAERETRGFNQDEIANLFTK
KEKRILGPVLGLVGNALGGLIKKIG
Length 145
Signal peptide class Class-3
References:
1. for MIC/HC50 R. Liu et al. / Journal of Proteome Research 10 (2011) 1806-1815. There are abundant antimicrobial peptides in brains of two kinds of Bombina toads; R. Lai et al. / Peptides 23 (2002) 427-435. Antimicrobial peptides from skin secretions of Chinese red belly toad Bombina maxima
2. for other activities R. Lai et al. / Peptides 23 (2002) 427-435. Antimicrobial peptides from skin secretions of Chinese red belly toad Bombina maxima


Segment type Name Length Amidated Sequence HC50 (μM) MIC E. coli (μM) MIC S. aureus (μM)
Signal   18   MNFKYIVAVSFLIASAYA    
Prepro26 RSVQNDEQSLSQRDVLEEEESLREIR   
BioactiveMaximin 327YesGIGGKILSGLKTALKGAAKELASTYLH 3.51.74
Prepro53 RKRTAEEHEVMKRLEAVMRDLDSLDYPEEAAERETRGFNQDEIANLFTKKEKR   
BioactiveMaximin H320YesILGPVLGLVGNALGGLIKKI 10.295.15