Dermaseptin-2

Entry Dermaseptin-2
Uniprot code P84922
Fasta P84922
Peptide names Insulin-releasing-peptide Dermaseptin-B4 Dermaseptin-2 IRS Dermaseptin-TR1
Suborder Neobatrachia
Family Hylidae
Genus Phyllomedusa
Species Phyllomedusa tarsius
Ecozone Neotropic
Distribution Amazon Basin in southern Colombia, Ecuador, Peru, and Brazil, with seemingly isolated populations along the lowlands on the eastern side of the Merida Andes as well as in Barinas Province in eastern Venezuela
Antimicrobial & other activities antibacterial, insulin releasing
Tissue Skin
Sequence
Length 28
References:
1. for MIC/HC50 S. Charpentier et al. / The Journal of Biological Chemistry 273 (1998) 14690-14697. Structure, synthesis, and molecular cloning of dermaseptins B, a family of skin peptide antibiotics
2. for other activities M. Amiche et al. / Peptides 29 (2008) 2074-2082. A consistent nomenclature of antimicrobial peptides isolated from frogs of the subfamily Phyllomedusinae


Segment type Name Length Amidated Sequence HC50 (μM) MIC E. coli (μM) MIC S. aureus (μM)
BioactiveDermaseptin-228YesALWKDILKNVGKAAGKAVLNTVTDMVNQ 53