Dermaseptin-5

Entry Dermaseptin-5
Uniprot code P84600
Fasta P84600
Peptide names Dermaseptin-01 Dermaseptin DS 01 Dermaseptin-5 Dermaseptin-H6
Suborder Neobatrachia
Family Hylidae
Genus Phyllomedusa
Species Phyllomedusa hypochondrialis
Ecozone Neotropic
Distribution Eastern Colombia east through northern and eastern Venezuela, through the Guianas and throughout Brazilian Amazonia; currently not known from Amazonian Colombia, Peru, Ecuador, or Bolivia
Antimicrobial & other activities antibacterial, antifungal
Tissue Skin
Sequence
Length 29
References:
1. for MIC/HC50 G.D. Brand et al. / JBC 277 (2002) 49332-49340. Dermaseptins from Phyllomedusa oreades and Phyllomedusa distincta. Anti-Trypanosoma cruzi activity without cytotoxicity to mammalian cells;  J.R.S.A. Leite et al. / Comparative Biochemistry and Physiology, Part A 151 (2008) 336-343. Dermaseptins from Phyllomedusa oreades and Phyllomedusa distincta: Secondary structure, antimicrobial activity, and mammalian cell toxicity


Segment type Name Length Amidated Sequence HC50 (μM) MIC E. coli (μM) MIC S. aureus (μM)
BioactiveDermaseptin-529YesGLWSTIKQKGKEAAIAAAKAAGQAALGAL 6.423.2