Phylloseptin-2

Entry Phylloseptin-2
Uniprot code P84567
Fasta P84567
Peptide names Phylloseptin-2 Phylloseptin PS2
Suborder Neobatrachia
Family Hylidae
Genus Phyllomedusa
Species Phyllomedusa hypochondrialis
Ecozone Neotropic
Distribution Eastern Colombia east through northern and eastern Venezuela, through the Guianas and throughout Brazilian Amazonia; currently not known from Amazonian Colombia, Peru, Ecuador, or Bolivia
Antimicrobial & other activities antibacterial, antifungal
Tissue Skin
Sequence MAFLKKSLFLVLFLGLATLSICEEEKRETEEEEYNQEEDDKSEEKRFLSLIPHAINAVST
LVHHFG
Length 66
Signal peptide class Class-1
References:
1. for MIC/HC50 J.M. Resende et al. / Peptides 29 (2008) 1633-1644. Solution NMR structures of the antimicrobial peptides phylloseptin-1, -2, and -3 and biological activity: The role of charges and hydrogen bonding interactions in stabilizing helix conformations


Segment type Name Length Amidated Sequence HC50 (μM) MIC E. coli (μM) MIC S. aureus (μM)
Signal   22   MAFLKKSLFLVLFLGLATLSIC    
Prepro24 EEEKRETEEEEYNQEEDDKSEEKR   
BioactivePhylloseptin-219YesFLSLIPHAINAVSTLVHHF 3.71.9