Kininogen-2

Entry Kininogen-2
Uniprot code P83059
Fasta P83059
Peptide names [Thr6]-bradykinin Kininogen-2 Bradykinin inhibitor peptide DV-28
Suborder Archeobatrachia
Family Bombinatoridae
Genus Bombina
Species Bombina orientalis
Ecozone Palearctic
Distribution Southern part of Russian Far East (Primorye Region and a few localities in the Khabarovskii Region); northeastern China (from northeastern Inner Mongolia and Heilongjiang south to southern Liaoning, with one locality in the Beijing area and other records in eastern Shandong and eastern Jiangsu) and Korea; Tsushima and Kyushu Islands, Japan
Antimicrobial & other activities [Thr6]-bradykinin: contraction of small intestine smooth muscle cells, relaxation of arterial smooth muscle cells; peptide DV-28: inhibition the bradykinin-induced contraction of small intestine smooth muscle cells and relaxation of arterial smooth muscle cells
Tissue Skin
Sequence MRLWFCLSFFVVLCLEHFPGTLADERNNRDYPIRTHLHGPHIPRNNRDYPIRTHLHGHHI
PRNVPESEEKTEQFLRDLSEISRLQRRPPGFTPFRGKFHSQSLRDLSEISRLQRRPPGFT
PFRGKFHSQSLRDMYEIKGFKSAHGRPRVCPPGEQCPIWVG
Length 161
Signal peptide class Class-5
References:
2. for other activities T. Chen et al. / Peptides 23 (2002) 1547-1555. Bradykinins and their precursor cDNAs from the skin of the fire-bellied toad (Bombina orientalis)


Segment type Name Length Amidated Sequence HC50 (μM) MIC E. coli (μM) MIC S. aureus (μM)
Signal   23   MRLWFCLSFFVVLCLEHFPGTLA    
Prepro63 DERNNRDYPIRTHLHGPHIPRNNRDYPIRTHLHGHHIPRNVPESEEKTEQFLRDLSEISRLQR   
Bioactive[Thr6]-bradykinin9NoRPPGFTPFR   
Bioactive[Thr6]-bradykinin10NoRRPPGFTPFR   
BioactiveBradykinin inhibitor peptide DV-2828NoDMYEIKGFKSAHGRPRVCPPGEQCPIWV