Kininogen-2

Entry Kininogen-2
Uniprot code P83057
Fasta P83057
Peptide names [Val1,Thr3,Thr6]-bradykinin Kininogen-2 Kininogen-2-associated peptide
Suborder Archeobatrachia
Family Bombinatoridae
Genus Bombina
Species Bombina variegata
Ecozone Palearctic
Distribution Europe excluding the Iberian Peninsula and Italy south of the Po River in Italy, east to western Ukraine and Moldova; introduced into England
Antimicrobial & other activities contraction of small intestine smooth muscle cells, relaxation of arterial smooth muscle cells
Tissue Skin
Sequence MILWFCLNFLIVLCLEHFPGTLAAERNVPQSEEKTEQFLRDLSEISRLQRVPTGFTPFRG
KFHSQSLRGLSETKKFKAPYNIHWHCKPGLLCKNFN
Length 96
Signal peptide class Class-5
References:
2. for other activities T. Chen et al. / European Journal of Biochemistry 269 (2002) 4693-4700. Novel bradykinins and their precursor cDNAs from European yellow-bellied toad (Bombina variegata) skin


Segment type Name Length Amidated Sequence HC50 (μM) MIC E. coli (μM) MIC S. aureus (μM)
Signal   23   MILWFCLNFLIVLCLEHFPGTLA    
Prepro27 AERNVPQSEEKTEQFLRDLSEISRLQR   
Bioactive[Val1,Thr3,Thr6]-bradykinin9NoVPTGFTPFR   
Prepro16 GKFHSQSLRGLSETKK   
BioactiveKininogen-2-associated peptide17NoFKAPYNIHWHCKPGLLC