| Entry | Bombinin-like peptides 2 |
| Uniprot code | P82286 |
| Fasta | P82286 |
| Peptide names | Bombinin-like peptide 2 Bombinin-like peptides 2 Bombinin H2 Bombinin-H5 Bombinin-H |
| Suborder | Archeobatrachia |
| Family | Bombinatoridae |
| Genus | Bombina |
| Species | Bombina variegata |
| Ecozone | Palearctic |
| Distribution | Europe excluding the Iberian Peninsula and Italy south of the Po River in Italy, east to western Ukraine and Moldova; introduced into England |
| Antimicrobial & other activities | antibacterial; Bombinin-H2: antibacterial, antifungal, antiprotozoa |
| Tissue | Skin, Brain, Stomach |
| Sequence | MNFKYIVAVSILIASAYARREENNIQSLSQRDVLEEESLREIRGIGASILSAGKSALKGF AKGLAEHFANGKRTAEDHEMMKRLEAAVRDLDSLEHPEEASEKETRGFNQEEKEKRIIGP VLGLVGSALGGLLKKIG |
| Length | 137 |
| Signal peptide class | Class-3 |
| References: | |
| 1. for MIC/HC50 | M. Simmaco et al. / Biochimica et Biophysica Acta 1788 (2009) 1551-1555. Bombinins, antimicrobial peptides from Bombina species |
| 2. for other activities | B.W. Gibson et al. / The Journal of Biological Chemistry 266 (1991) 23103-23111. Bombinin-like peptides with antimicrobial activity from scin secreations from Asian toad, Bombina orientalis |
| Segment type | Name | Length | Amidated | Sequence | HC50 (μM) | MIC E. coli (μM) | MIC S. aureus (μM) |
| Signal | 18 | MNFKYIVAVSILIASAYA | |||||
| Prepro | 25 | RREENNIQSLSQRDVLEEESLREIR | |||||
| Bioactive | Bombinin-like peptide 2 | 27 | No | GIGASILSAGKSALKGFAKGLAEHFAN | |||
| Prepro | 46 | GKRTAEDHEMMKRLEAAVRDLDSLEHPEEASEKETRGFNQEEKEKR | |||||
| Bioactive | Bombinin-H2 | 20 | Yes | IIGPVLGLVGSALGGLLKKI | 4.4 | 4.7 |