Dermaseptin BI

Entry Dermaseptin BI
Uniprot code P80282
Fasta P80282
Peptide names Dermaseptin BI Dermaseptin B1 DRS-B1
Suborder Neobatrachia
Family Hylidae
Genus Phyllomedusa
Species Phyllomedusa bicolor
Ecozone Neotropic
Distribution Amazon Basin in Brazil, Colombia, Bolivia, and Peru; the Guianan region of Venezuela and the Guianas. Possibly to be found in eastern Ecuador
Antimicrobial & other activities antibacterial, antifungal, antiprotozoa
Tissue Skin
Sequence MDILKKSLFLVLFLGLVSLSICEEEKRENEDEEKQDDEQSEMKRAMWKDVLKKIGTVALH
AGKAALGAVADTISQGEQ
Length 78
Signal peptide class Class-1
References:
1. for MIC/HC50 P. Nicolas and C. El Amri / Biochimica et Biophysica Acta 1788 (2009) 1537-1550. The dermaseptin superfamily: a gene-based combinatorial library of antimicrobial peptides. The dermaseptin superfamily: a gene-based combinatorial library of antimicrobial peptides


Segment type Name Length Amidated Sequence HC50 (μM) MIC E. coli (μM) MIC S. aureus (μM)
Signal   22   MDILKKSLFLVLFLGLVSLSIC    
Prepro22 EEEKRENEDEEKQDDEQSEMKR   
BioactiveDermaseptin BI31NoAMWKDVLKKIGTVALHAGKAALGAVADTISQ>250.001.512.5