Dermorphin-1

Entry Dermorphin-1
Uniprot code P05422
Fasta P05422
Peptide names Deltorphin Dermorphin-1 Dermorphin
Suborder Neobatrachia
Family Hylidae
Genus Phyllomedusa
Species Phyllomedusa sauvagii
Ecozone Neotropic
Distribution The Chacoan region of eastern Bolivia, northern Paraguay, Mato Grosso do Sul (Brazil), and northern Argentina
Antimicrobial & other activities inhibition of ileum cells contraction, inhibition of vas deferens cells contraction, mu-receptor affinity, delta-receptor affinity, antinociceptive
Tissue Skin
Sequence MSFLKKSLLLILFLGLVSLSVCKEEKRETEEENENEENHEEGSEMKRYMFHLMDGEAKKR
DSEENEIEENHEEGSEMKRYAFGYPSGEAKKIKRVSEEENENEENHEEGSEMKRYAFGYP
SGEAKKIKRESEEEKEIEENHEEGSEMKRYAFGYPSGEAKKIKRESEEENENEENHEEGS
EMKRYAFGYPSGEAKKM
Length 197
Signal peptide class Class-1
References:
2. for other activities K. Richter et al. / PNAS 87 (1990) 4836-4839. cDNAs encoding [D-Ala2]deltorphin precursors from skin of Phyllomedusa bicolor also contain genetic information for three dermorphin-related opioid peptides


Segment type Name Length Amidated Sequence HC50 (μM) MIC E. coli (μM) MIC S. aureus (μM)
Signal   22   MSFLKKSLLLILFLGLVSLSVC    
Prepro25 KEEKRETEEENENEENHEEGSEMKR   
BioactiveDeltorphin7NoYMFHLMD   
Prepro25 GEAKKRDSEENEIEENHEEGSEMKR   
BioactiveDermorphin7NoYAFGYPS   
Prepro28 GEAKKIKRVSEEENENEENHEEGSEMKR   
BioactiveDermorphin7NoYAFGYPS   
Prepro28 GEAKKIKRESEEEKEIEENHEEGSEMKR   
BioactiveDermorphin7NoYAFGYPS   
Prepro28 GEAKKIKRESEEENENEENHEEGSEMKR   
BioactiveDermorphin7NoYAFGYPS