Preprocaerulein type-4

Entry Preprocaerulein type-4
Uniprot code P05226
Fasta P05226
Peptide names Caerulein Preprocaerulein type-4
Suborder Mesobatrachia
Family Pipidae
Genus Xenopus
Species Xenopus borealis
Ecozone Afrotropic
Distribution Savanna in northern Tanzania, and central and northern Kenya, above 1500 m elevation. One record for southern Tanzania
Antimicrobial & other activities fall of the blood pressure, contraction of the gall bladder, stimulating acid secretion of the stomach, increasing the pancreatic juice secretion
Tissue Skin
Sequence MFKGILLCVLFAVLSANPLSQPEGFADEEERDVRGLASLLGKALKAALKIGANALGGSPQ
QREANDERRFADGQQDYTGWMDFGRRDDEDDVNERDVRGFGSFLGKALKAGLKIGTHFLG
GAPQQREANDERRFADGQQDYTGWMDFGRRDGQQDYTGWMDFGRRDDEDDVHERDVRGFG
SFLGKALKAALKIGANALGGSPQQREANDERRFADGQQDYTGWMDFGRRNGEDD
Length 234
Signal peptide class Class-4
References:
2. for other activities A. Anastasi et al. / British Journal of Pharmacology 38 (1970) 221-228. Presence of caerulein in extracts of the skin of Leptodactylus pentadactylus labyrinthicus and of Xenopus laevis


Segment type Name Length Amidated Sequence HC50 (μM) MIC E. coli (μM) MIC S. aureus (μM)
Signal   26   MFKGILLCVLFAVLSANPLSQPEGFA    
Prepro47 DEEERDVRGLASLLGKALKAALKIGANALGGSPQQREANDERRFADG   
BioactiveCaerulein10NoQQDYTGWMDF   
Prepro54 GRRDDEDDVNERDVRGFGSFLGKALKAGLKIGTHFLGGAPQQREANDERRFADG   
BioactiveCaerulein10NoQQDYTGWMDF   
Prepro5 GRRDG   
BioactiveCaerulein10NoQQDYTGWMDF   
Prepro54 GRRDDEDDVHERDVRGFGSFLGKALKAALKIGANALGGSPQQREANDERRFADG   
BioactiveCaerulein10NoQQDYTGWMDF