Dermaseptin PD-3-6

Entry Dermaseptin PD-3-6
Uniprot code O93454
Fasta O93454
Peptide names Dermaseptin PD-3-6 DRP-PD-3-6
Suborder Neobatrachia
Family Hylidae
Genus Pachymedusa
Species Pachymedusa dacnicolor
Ecozone Neotropic
Distribution Pacific lowlands of Mexico from southern Sonora south (including the Balsas Depression to the state of Mexico) to the Isthmus of Tehuantepec
Antimicrobial & other activities antibacterial
Tissue Skin
Sequence MAFLKKSLFLVLFLALVPLSICEAEKREEENEEKQEDDDESEKKRGVVTDLLNTAGGLLG
NLVGSLSGGER
Length 71
Signal peptide class Class-1
References:
1. for MIC/HC50 P. Nicolas and C. El Amri / Biochimica et Biophysica Acta 1788 (2009) 1537-1550. The dermaseptin superfamily: a gene-based combinatorial library of antimicrobial peptides


Segment type Name Length Amidated Sequence HC50 (μM) MIC E. coli (μM) MIC S. aureus (μM)
Signal   22   MAFLKKSLFLVLFLALVPLSIC    
Prepro23 EAEKREEENEEKQEDDDESEKKR   
BioactiveDermaseptin PD-3-623NoGVVTDLLNTAGGLLGNLVGSLSG50 250