[Arg0, Trp5, Leu8]-bradykinin precursor

Entry [Arg0, Trp5, Leu8]-bradykinin precursor
Uniprot code E7AIL2
Fasta E7AIL2
Peptide names bradykinin precursor [Arg0, Trp5, Leu8]-bradykinin precursor
Suborder Neobatrachia
Family Ranidae
Genus Rana
Species Pelophylax esculentus
Ecozone Palearctic
Distribution Most of western, central and eastern Europe, Denmark and suthern most Sweden, Italy (river Po plain), up to 1550 m elevation. Introduced to United Kingdom and Spain.
Antimicrobial & other activities contraction of arterial smooth muscle cells
Tissue Skin
Sequence MFTMKKSLLLFFFLGIVSLSLCKEERDADEEENEETGGEVKVEEVKRQKTYNRRPPGWSP
LRIAPTNV
Length 68
Signal peptide class Class-1
References:
2. for other activities X. Chen et al. / Peptides 32 (2011) 26-30. A fish bradykinin (Arg0, Trp5, Leu8-bradykinin) from the defensive skin secretion of the European edible frog, Pelophylax kl. esculentus: structural characterization;  molecular cloning of skin kininogen cDNA and pharmacological effects on mammalian smooth muscle


Segment type Name Length Amidated Sequence HC50 (μM) MIC E. coli (μM) MIC S. aureus (μM)
Signal   22   MFTMKKSLLLFFFLGIVSLSLC    
Prepro25 KEERDADEEENEETGGEVKVEEVKR   
Bioactivebradykinin precursor10NoRRPPGWSPLR