Maximin 42/H4

Entry Maximin 42/H4
Uniprot code C3RSX8
Fasta C3RSX8
Peptide names Maximin 42/H4 Maximin 42 Maximin H4
Suborder Archeobatrachia
Family Bombinatoridae
Genus Bombina
Species Bombina maxima
Ecozone Palearctic, Indomalaya
Distribution Yunnan, southwestern Sichuan, Hubei, Guizhou, and northern Guangxi, China; adjacent northern Vietnam
Antimicrobial & other activities antibacterial; Maximin H4: antibacterial, antifungal
Tissue Skin, Brain
Sequence MNFKYIVAVSFLIASAYARSEENDEQSLSQRDVLEEESLREIRSIGAKILGGVKTFFKGA
LKELAFTYLQRKRTAEEQHEVMKRLEAVMRDLDSLDHPEEAFERETRGFNQEEIANHFTK
KEKRILGPVISKIGGVLGGLLKNLG
Length 145
Signal peptide class Class-3
References:
1. for MIC/HC50 R. Liu et al. / Journal of Proteome Research 10 (2011) 1806-1815. There are abundant antimicrobial peptides in brains of two kinds of Bombina toads; R. Lai et al. / Peptides 23 (2002) 427-435. Antimicrobial peptides from skin secretions of Chinese red belly toad Bombina maxima


Segment type Name Length Amidated Sequence HC50 (μM) MIC E. coli (μM) MIC S. aureus (μM)
Signal   18   MNFKYIVAVSFLIASAYA    
Prepro25 RSEENDEQSLSQRDVLEEESLREIR   
BioactiveMaximin 4227YesSIGAKILGGVKTFFKGALKELAFTYLQ  12.92
Prepro54 RKRTAEEQHEVMKRLEAVMRDLDSLDHPEEAFERETRGFNQEEIANHFTKKEKR   
BioactiveMaximin H420YesILGPVISKIGGVLGGLLKNL 6.123.06