Antimicrobial peptide

Entry Antimicrobial peptide
Uniprot code C3RSQ4
Fasta C3RSQ4
Peptide names Antimicrobial peptide Maximin 28
Suborder Archeobatrachia
Family Bombinatoridae
Genus Bombina
Species Bombina maxima
Ecozone Palearctic, Indomalaya
Distribution Yunnan, southwestern Sichuan, Hubei, Guizhou, and northern Guangxi, China; adjacent northern Vietnam
Antimicrobial & other activities antibacterial, antifungal
Tissue Skin, Brain
Sequence MNFKYIVAVSFLIASAYARSEENDERSLSQRDVLEEESLREIRGIGTKFLGGVKTALKGA
LKELASTYVNGKRTAEDHEVMKRLEAVMRDLDSLDYPEEAAERETRGFNEEEIANLFTKK
EKRILGLVISTIGNVLGGLLKNLG
Length 144
Signal peptide class Class-3
References:
1. for MIC/HC50 R. Liu et al. / Journal of Proteome Research 10 (2011) 1806-1815. There are abundant antimicrobial peptides in brains of two kinds of Bombina toads


Segment type Name Length Amidated Sequence HC50 (μM) MIC E. coli (μM) MIC S. aureus (μM)
Signal   18   MNFKYIVAVSFLIASAYA    
Prepro25 RSEENDERSLSQRDVLEEESLREIR   
BioactiveMaximin 2827YesGIGTKFLGGVKTALKGALKELASTYVN1003.431.72
Prepro53 GKRTAEDHEVMKRLEAVMRDLDSLDYPEEAAERETRGFNEEEIANLFTKKEKR   
BioactiveAntimicrobial peptide20NoILGLVISTIGNVLGGLLKNL