Maximin 25/H3

Entry Maximin 25/H3
Uniprot code B5L104
Fasta B5L104
Peptide names Maximin 25 Maximin 25/H3 Maximin 3 Maximin H3
Suborder Archeobatrachia
Family Bombinatoridae
Genus Bombina
Species Bombina maxima
Ecozone Palearctic, Indomalaya
Distribution Yunnan, southwestern Sichuan, Hubei, Guizhou, and northern Guangxi, China; adjacent northern Vietnam
Antimicrobial & other activities antibacterial, antifungal, anticancer, anti-HIV-1, spermicidal; Maximin H3: antibacterial, antifungal
Tissue Skin, Brain
Sequence MNFKYIVAVSFLIASAYARSVQNDEQSLSQRDVLEEESLREIRGIGGKILSGLKTALKGA
AKELASTYLHRKRTAEEHEVMKRLEAVMRDLDSLDYPEEAFERETRGFNQDEIANLFTKK
EKRILGPVLGLVGNALGGLIKKIG
Length 144
Signal peptide class Class-3
References:
1. for MIC/HC50 R. Liu et al. / Journal of Proteome Research 10 (2011) 1806-1815. There are abundant antimicrobial peptides in brains of two kinds of Bombina toads; R. Lai et al. / Peptides 23 (2002) 427-435. Antimicrobial peptides from skin secretions of Chinese red belly toad Bombina maxima
2. for other activities R. Lai et al. / Peptides 23 (2002) 427-435. Antimicrobial peptides from skin secretions of Chinese red belly toad Bombina maxima


Segment type Name Length Amidated Sequence HC50 (μM) MIC E. coli (μM) MIC S. aureus (μM)
Signal   18   MNFKYIVAVSFLIASAYA    
Prepro25 RSVQNDEQSLSQRDVLEEESLREIR   
BioactiveMaximin 2527YesGIGGKILSGLKTALKGAAKELASTYLH1003.51.74
Prepro53 RKRTAEEHEVMKRLEAVMRDLDSLDYPEEAFERETRGFNQDEIANLFTKKEKR   
BioactiveMaximin H320YesILGPVLGLVGNALGGLIKKI 10.295.15