Caerin 1.1

Entry Caerin 1.1
Uniprot code B5AKW5
Fasta B5AKW5
Peptide names Caerin-1.1 Caerin 1.1
Suborder Neobatrachia
Family Hylidae
Genus Litoria
Species Litoria caerulea
Ecozone Australasia
Distribution Northern and eastern Australia (except for the Victoria and Tasmania); islands in the Torres Straits; New Guinea (northern lowlands, southern lowlands, and Vogelkop Peninsula); introduced into New Zealand
Antimicrobial & other activities antibacterial, anticancer, antifungal, nNOS inhibitor
Tissue Skin
Sequence MAFLKKSLFLGLFLGFVSVSICEEEKRQEDEDEHDEEGENQEEGSEEKRGLLSVLGSVAK
HVLPHVVPVIAEHLG
Length 75
Signal peptide class Class-1
References:
1. for MIC/HC50 M.A. Apponyi et al. / Peptides 25 (2004) 1035-1054. Host-defence peptides of Australian anurans: structure, mechanism of action and evolutionary significance;  P.A. Wabnitz et al. / European Journal of Biochemistry 267 (2000) 269-275. Differences in the skin peptides of the male and female Australian tree frog Litoria splendida. The discovery of the aquatic male sex pheromone splendipherin, together with phe8 caerulein and a new antibiotic peptide caerin 1.10
2. for other activities R.J. Jackway et al. / Peptides 32 (2011) 161-172. Skin peptide and cDNA profiling of Australian anurans: genus and species identification and evolutionary trends


Segment type Name Length Amidated Sequence HC50 (μM) MIC E. coli (μM) MIC S. aureus (μM)
Signal   22   MAFLKKSLFLGLFLGFVSVSIC    
Prepro27 EEEKRQEDEDEHDEEGENQEEGSEEKR   
BioactiveCaerin 1.125YesGLLSVLGSVAKHVLPHVVPVIAEHL  1.16