Kininogen-1

Entry Kininogen-1
Uniprot code A5PG36
Fasta A5PG36
Peptide names RR-13 Kininogen-1 bradykinin RR-13-(Phe12) RR-13 RR-13-(Glu2,Asn3) AA-15
Suborder Neobatrachia
Family Ranidae
Genus Lithobates
Species Lithobates palustris
Ecozone Palearctic
Distribution Eastern North America, from southern Quebec through southern Ontario (Canada) south through extreme eastern Minnesota and on to East Texas then east to South Carolina (USA), extreme western Florida, and north to Nova Scotia (Canada)
Antimicrobial & other activities contraction of small intestine smooth muscle cells, relaxation of arterial smooth muscle cells
Tissue Skin
Sequence MFTLKKSLLLLFFLGTISLSLCEQERDADEDEYAGDAKAEDVKRAGYSRVISLPAGLSPL
RIAPASSRMIRRPPGFSPFRIAPASTLKRDADEDEYAGEAKAEDVKRAGYSRVISLPAGL
SPFRIAPASTLKRDADEDEYAGEAKAEDVKRAGYARVISLPAGLSPLRIAPASTLKRDAD
EDEYAGEAKAEDVKRAGYARVISLPAGLSPLRIAPASTLKRDADEDEYAGEAKAEDVKRA
RYSRENSLPAGLSPLRIAPASTLKRDADEDEYAGEAKAEDVKRAGIRRPPGFSPLRIAPA
SSRMIRRPPGFSPFRIAPAIV
Length 321
Signal peptide class Class-1
References:
2. for other activities T. Chen et al. / Peptides 23 (2002) 1547-1555. Bradykinins and their precursor cDNAs from the skin of the fire-bellied toad (Bombina orientalis)


Segment type Name Length Amidated Sequence HC50 (μM) MIC E. coli (μM) MIC S. aureus (μM)
Signal   22   MFTLKKSLLLLFFLGTISLSLC    
Prepro26 EQERDADEDEYAGDAKAEDVKRAGYS   
BioactiveRR-1313NoRVISLPAGLSPLR   
Prepro10 IAPASSRMIR   
Bioactivebradykinin9NoRPPGFSPFR   
Prepro31 IAPASTLKRDADEDEYAGEAKAEDVKRAGYS   
BioactiveRR-13-(Phe12)13NoRVISLPAGLSPFR   
Prepro31 IAPASTLKRDADEDEYAGEAKAEDVKRAGYA   
BioactiveRR-1313NoRVISLPAGLSPLR   
Prepro31 IAPASTLKRDADEDEYAGEAKAEDVKRAGYA   
BioactiveRR-1313NoRVISLPAGLSPLR   
Prepro31 IAPASTLKRDADEDEYAGEAKAEDVKRARYS   
BioactiveRR-13-(Glu2,Asn3)13NoRENSLPAGLSPLR   
Prepro27 IAPASTLKRDADEDEYAGEAKAEDVKR   
BioactiveAA-1515NoAGIRRPPGFSPLRIA   
Prepro8 PASSRMIR   
Bioactivebradykinin9NoRPPGFSPFR