OGTI precursor AF-43

Entry OGTI precursor AF-43
Peptide names OGTI Ranatuerin-2SHb Ranatuerin-2R-RA2 Ranatuerin-2-MG1 Andersonin-W2
Suborder Neobatrachia
Family Ranidae
Genus Odorrana
Species Odorrana grahami
Ecozone Palearctic, Indomalaya
Distribution Sichuan, Guizhou, and central and western Yunnan, China; a distantly alloparic population present in southern Shanxi, China: presumably to be found in eastern Myanmar along the Yunna, China, border; reported in Lao Cai and Lai Chau provinces, Vietnam, 1150-3200 m elevation
Antimicrobial & other activities antibacterial, serine protease inhibitor
Tissue Skin
Sequence MFTLKKSLLLLFFLGFISLSLCEEERDANEERRDDPDENEANEGEAKVEEIKRAVNIPFK
VHFRCKAAFC
Length 70
Signal peptide class Class-1
References:
1. for MIC/HC50 X. Yang et al. / Journal of Proteome Research 11 (2012) 306-319. Extremely Abundant Antimicrobial Peptides Existed in the Skins of Nine Kinds of Chinese Odorous Frogs
2. for other activities J. Li et al. / Biochimie 90 (2008) 1356-1361. A small trypsin inhibitor from the frog of Odorrana grahami


Segment type Name Length Amidated Sequence HC50 (μM) MIC E. coli (μM) MIC S. aureus (μM)
Signal   22   MFTLKKSLLLLFFLGFISLSLC    
Prepro31 EEERDANEERRDDPDENEANEGEAKVEEIKR   
BioactiveOGTI17NoAVNIPFKVHFRCKAAFC 10.355.18